What is Lymphedema of The Legs?

Say Goodbye to Compression Garments after Dr. Cheng’s Lymphedema Microsurgery

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Lower Extremity Lymphedema?

Lymphadenectomy in uterine cancer is important for surgical staging and for cancer treatment by decreasing metastasis via lymphatic channels. It is estimated that from 10% to 49% of patients who were treated for gynecological cancer ablation, pelvic lymph nodes dissection and postoperative radiotherapy develop gynecologic cancer-related lymphedema (GCRL). Risk factors for GCRL include high body mass index, a greater number of pelvic lymph nodes removed, especially when more than 10 nodes are removed, and the dosage of radiation therapy. The incidence is higher after cancer resection and lymph node dissection in vulva cancer followed by cervical and ovarian cancer. Recently, sentinel lymph node biopsy was selectively applied in gynecological cancer surgery to reduce the lower limb lymphedema.

 

Symptoms of Leg Lymphedema

Lymphedema then presents as chronic changes and swelling of the tissue and is often associated with adipogenesis or fibrotic changes in the lower limb as well. Severe fibrosis occurs with long-standing lymphedema due to the accumulation of protein-rich fluid in the interstitial spaces coupled with inflammation repeated bouts of cellulitis. It is common for lymphedema patients to experience depression, due to the physical discomfort, emotional distress and lowered quality of life.

 

Diagnosis of Leg Lymphedema

Dr. Ming-Huei Cheng developed a Cheng’s Lymphedema Grading tool to assess the severity of extremity lymphedema. Cheng Lymphedema Grading System is currently the most common used measurement, it is based on not only subjective criteria and clear objective findings that could facilitate discussions and meaningful comparison of the treatment proposed. If the contralateral limb is uninvolved, the circumferential measurements comparing between the affected and the normal side is a more objective method for quantifying the clinical severity of lymphedema. This objective method has been demonstrated being consistent and reproducible. In addition, imaging modalities such as lymphoscintigraphy, computed tomography (CT), magnetic resonance imaging (MRI) and indocyanine green (ICG) lymphography could play a role for the diagnosis and severity of lymphedema. For many years, lymphoscintigraphy has been widely adopted for investigating the functional status of the lymphatic system, proving to be 96% sensitive and 100% specific for lymphedema. Our studies have proposed staging systems of lymphoscintigraphy.

 

Treatment of Lower Extremity

Treatments of lymphedema are aimed to control infection, to reduce the swelling of the extremity and to improve the quality of life. Basic treatments of lymphedema start with conservative physical therapy, including manual lymphatic drainage and compression bandage-centered decongestive lymphatic therapy. The efficacy of conservative physical therapy presents only when the patients are compliant with the treatment program. However, it also carries risks of intravascular cancer metastasis and thrombosis formation. Surgical treatments are indicated when first line conservative measures fail and when patients present with late stage disease. There are two main categories of surgical treatment: excisional and physiologic procedures. Excisional procedures are essentially a surgical reduction of excess fibro-adipose tissue in the affected limb while physiologic procedures reconstruct the lymphatic system to improve physiologic drainage. Surgical treatments are also “be cure and control”, the goals of treatment are similarly preventing progression of disease and reducing morbidities.

Debulky surgery and circumferential suction-assisted lipectomy can be performed to reduce the severely, non-pitting lymphedematous extremity. More technical demanding surgeries, such as lymphaticovenous anastomosis and Free vascularized lymph node transfer The basic physiologic mechanism of the vascularized lymph node flap is that lymph is absorbed by the transferred lymph nodes and drained into a donor vein through natural lymphaticovenous connections inside a flap. The arterial flow from the recipient artery to the vascularized lymph node flap provides the driving force for venous return and hence, continuous lymph drainage. We report the transfer of a vascularized submental lymph node flap to the ankle is a novel approach for the effective treatment of lower extremity lymphedema. There was no donor site morbidity. At a mean follow-up of 8.7 ± 4.2 months, the mean reduction of the leg circumfer- ence was 64±11.5% above the knee, 63.7±34.3% below the knee and 67.3±19.2% above the ankle. All of the patients did not use compression garments post-operatively!

 

Recommended reading journal:

  1. A novel approach to the treatment of lower extremity lymphedema by transferring a vascularized submental lymph node flap to the ankle.
    Cheng MH, Huang JJ, Nguyen DH, Saint-Cyr M, Zenn MR, Tan BK, Lee CL.
    Gynecol Oncol. 2012 Jul;126(1):93-8.
    https://www.ncbi.nlm.nih.gov/pubmed/22516659
  2. Simultaneous Bilateral Submental Lymph Node Flaps for Lower Limb Lymphedema Post Leg Charles Procedure.
    Ito R, Lin MC, Cheng MH.
    Plast Reconstr Surg Glob Open. 2015 Sep 15;3(9):e513.
    https://www.ncbi.nlm.nih.gov/pubmed/26495226
  3. Vascularized lymph node transfer for treatment of extremity lymphedema: An overview of current controversies regarding donor sites, recipient sites and outcomes.
    Pappalardo M, Patel K, Cheng MH.
    J Surg Oncol. 2018 Jun;117(7):1420-1431.
    https://www.ncbi.nlm.nih.gov/pubmed/29572824
  4. Correlation between Quantity of Transferred Lymph Nodes and Outcome in Vascularized Submental Lymph Node Flap Transfer for Lower Limb Lymphedema.
    Gustafsson J, Chu SY, Chan WH, Cheng MH.
    Plast Reconstr Surg. 2018 Jul 10.
    https://www.ncbi.nlm.nih.gov/pubmed/30020232
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